Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 3/20 | 0.48 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.48 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7162165 | 0.99 | LTA4H (0.49) | S1PR1S1PR2S1PR3LPAR2LTA4H | |
| SCHEMBL3363347 | 0.85 | LSS (0.57) | MEN1KMT2A | |
| SCHEMBL3368283 | 0.83 | LSS (0.56) | LTA4HMEN1KMT2A | |
| SCHEMBL7166192 | 0.79 | THRA (0.49) | LTA4HLMNAHTTTHRATHRB | |
| SCHEMBL7162166 | 0.77 | THRA (0.47) | LTA4HLMNAHTTTHRATHRB | |
| SCHEMBL7629708 | 0.75 | LMNA (0.66) | S1PR1S1PR3LTA4HLMNATHRA | |
| SCHEMBL5725957 | 0.74 | NPC1 (0.58) | S1PR1S1PR2S1PR3LPAR2LMNA | |
| Symetine SCHEMBL1816051 | 0.73 | KCNH2 (0.59) | MEN1KMT2A | |
| SCHEMBL7173345 | 0.73 | LTA4H (0.45) | S1PR1S1PR2S1PR3LPAR2LTA4H | |
| SCHEMBL7625591 | 0.72 | LMNA (0.66) | S1PR1S1PR3LTA4HLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303503-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006189-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |