Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7166273 | 0.83 | SRC (0.53) | SRCJAK2JAK1LRRK2CDK1 | |
| SCHEMBL7166266 | 0.77 | SRC (0.52) | SRCADORA2AJAK2JAK1TYK2 | |
| SCHEMBL7202387 | 0.77 | JAK1 (0.44) | SRCADORA2AJAK2JAK1ACHE | |
| SCHEMBL7149804 | 0.74 | LMNA (0.39) | ADORA2ACDK1CDK4CCNB1CCNA2 | |
| SCHEMBL7161609 | 0.69 | HCRTR1 (0.51) | ACHEBCHE | |
| SCHEMBL4768430 | 0.68 | POLB (0.53) | JAK2JAK1ACHE | |
| SCHEMBL4764246 | 0.68 | BACE1 (0.51) | JAK2JAK1ACHEBCHE | |
| SCHEMBL4763764 | 0.66 | TGFBR1 (0.49) | JAK2JAK1TYK2JAK3LMNA | |
| SCHEMBL15288776 | 0.66 | ADORA2A (0.47) | ADORA2AACHECDK1KDRLMNA | |
| SCHEMBL16618011 | 0.66 | LMNA (0.45) | SRCKDRLMNAEGFRFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268431-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072711-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2001-10-04 | — | — | WO | disclosed |