Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7166266 | 0.88 | SRC (0.52) | SRCEGFRFYNMAP2K1JAK2 | |
| SCHEMBL7166270 | 0.83 | SRC (0.48) | SRCEGFRFYNMAP2K1JAK2 | |
| SCHEMBL7202389 | 0.78 | ALDH1A1 (0.43) | SRCEGFRFYNMAP2K1KDM4E | |
| SCHEMBL7149809 | 0.75 | ALDH1A1 (0.43) | SRCKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6223729 | 0.70 | ALDH1A1 (0.67) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL3232975 | 0.70 | SRC (1.00) | SRCEGFRFYNMAP2K1 | |
| SCHEMBL16618012 | 0.68 | RIOK3 (0.54) | SRCEGFRFYNMAP2K1KDM4E | |
| SCHEMBL28748064 | 0.67 | SRC (0.62) | SRCEGFRFYNMAP2K1JAK2 | |
| SCHEMBL7692261 | 0.66 | ADORA2A (0.45) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL4765678 | 0.66 | DRD2 (0.53) | ALDH1A1JAK2JAK1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268431-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072711-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2001-10-04 | — | — | WO | disclosed |