Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL71662 | 1.00 | ALDH1A1 (0.42) | ALDH1A1MAPTPOLBSMN1; SMN2RAB9A | |
| Hydrochloric Acid SCHEMBL72178 | 0.92 | ALDH1A1 (0.40) | ALDH1A1MAPTPOLBSMN1; SMN2RAB9A | |
| Hydrochloric Acid SCHEMBL73143 | 0.92 | ALDH1A1 (0.40) | ALDH1A1MAPTPOLBSMN1; SMN2RAB9A | |
| SCHEMBL73440 | 0.91 | ALDH1A1 (0.43) | ALDH1A1MAPTPOLBSMN1; SMN2RAB9A | |
| SCHEMBL71590 | 0.90 | ALDH1A1 (0.42) | ALDH1A1MAPTPOLBSMN1; SMN2RAB9A | |
| SCHEMBL71591 | 0.90 | ALDH1A1 (0.42) | ALDH1A1MAPTPOLBSMN1; SMN2RAB9A | |
| Hydrochloric Acid SCHEMBL73441 | 0.90 | ALDH1A1 (0.42) | ALDH1A1MAPTPOLBSMN1; SMN2CYP3A4 | |
| Hydrochloric Acid SCHEMBL73439 | 0.90 | ALDH1A1 (0.42) | ALDH1A1MAPTPOLBSMN1; SMN2CYP3A4 | |
| SCHEMBL71446 | 0.90 | ALDH1A1 (0.48) | ALDH1A1MAPTPOLBSMN1; SMN2RAB9A | |
| SCHEMBL72207 | 0.90 | ALDH1A1 (0.51) | ALDH1A1MAPTPOLBSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130065882-A1 | VLA-4 inhibitory drug | MACHINAGA NOBUO (JP) | 2013-03-14 | — | — | US | disclosed |
| US-20120157437-A1 | VLA-4 INHIBITORY DRUG | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-06-21 | — | — | US | disclosed |
| US-8129366-B2 | VLA-4 inhibitory drug | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-20090233901-A1 | VLA-4 INHIBITORY DRUG | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157437-A1 | VLA-4 INHIBITORY DRUG | VCAM1, ITGB4, ITGA4 | ALDH1A1 216/4885MAPT 4775/4885POLB 3346/4885 |
| US-20130065882-A1 | VLA-4 inhibitory drug | VCAM1, ITGB4, ITGA4 | ALDH1A1 207/4885MAPT 4773/4885POLB 3839/4885 |
| US-20090233901-A1 | VLA-4 INHIBITORY DRUG | VCAM1, ITGB4, ITGA4 | ALDH1A1 525/4885MAPT 4795/4885POLB 3232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.