Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 7/20 | 0.70 |
| ▸ | TCF4 | P15884 | 1/20 | 0.60 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7573928 | 0.87 | CYP2C9 (0.82) | CYP2C9TCF4CTNNB1ALDH1A1LMNA | |
| SCHEMBL28560173 | 0.85 | CYP2C9 (0.80) | CYP2C9TCF4CTNNB1ALDH1A1LMNA | |
| SCHEMBL1073233 | 0.83 | CYP2C9 (1.00) | CYP2C9TCF4CTNNB1ALDH1A1LMNA | |
| SCHEMBL3511736 | 0.82 | CYP2C9 (0.64) | CYP2C9TCF4CTNNB1ALDH1A1LMNA | |
| SCHEMBL24102911 | 0.81 | CYP2C9 (0.76) | CYP2C9TCF4CTNNB1ALDH1A1LMNA | |
| SCHEMBL22391857 | 0.81 | CYP2C9 (0.76) | CYP2C9TCF4CTNNB1ALDH1A1LMNA | |
| SCHEMBL29535237 | 0.81 | CYP2C9 (0.76) | CYP2C9TCF4CTNNB1ALDH1A1LMNA | |
| SCHEMBL16119560 | 0.81 | CYP2C9 (0.76) | CYP2C9TCF4CTNNB1ALDH1A1LMNA | |
| SCHEMBL28702608 | 0.80 | CYP2C9 (0.67) | CYP2C9TCF4CTNNB1ALDH1A1LMNA | |
| SCHEMBL24102929 | 0.80 | CYP2C9 (0.79) | CYP2C9TCF4CTNNB1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030171376-A1 | Antiarthritic agents | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-09-11 | — | — | US | disclosed |
| US-6559149-B1 | Lesser side effects without compromise in their efficacy | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-05-06 | — | — | US | disclosed |
| EP-0632038-B1 | METHOTREXATE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2001-08-22 | — | — | EP | disclosed |
| EP-0632038-A1 | METHOTREXATE DERIVATIVE | Chugai Seiyaku Kabushiki Kaisha (JP) | 1995-01-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171376-A1 | Antiarthritic agents | BCOR, RCOR1, IL4 | CYP2C9 2757/4885TCF4 780/4885CTNNB1 3623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.