Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.36 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9255616 | 0.83 | PPARG (0.43) | POLBLMNABTN3A1CYP2C9CYP2C19 | |
| SCHEMBL2208720 | 0.78 | POLB (0.42) | POLBLMNACYP2C19CES1 | |
| SCHEMBL11517195 | 0.76 | PTPN1 (0.42) | POLBLMNACES1 | |
| SCHEMBL6672222 | 0.73 | MAPT (0.46) | POLBLMNAHDAC1HDAC2CYP2C19 | |
| SCHEMBL7695204 | 0.71 | PPARA (0.57) | HDAC1HDAC2 | |
| SCHEMBL10357848 | 0.71 | POLB (0.41) | POLBLMNACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL1700835 | 0.70 | SSTR4 (0.43) | HDAC1HDAC2SSTR4SSTR1CYP2C19 | |
| SCHEMBL17674534 | 0.70 | SSTR4 (0.43) | HDAC1HDAC2SSTR4SSTR1CYP2C19 | |
| SCHEMBL13908374 | 0.70 | FAAH (0.35) | CES1CYP1A2 | |
| SCHEMBL244446 | 0.70 | ALOX15 (0.52) | POLBLMNACYP2C9CYP2C19RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6555559-B1 | Prostaglandin I2 (PGI2); use as an anti-Helicobacter agent, a platelet function potentiating agent or a cervical ripening agent; side effect reduction | TORAY INDUSTRIES, INC. (JP) | 2003-04-29 | — | — | US | disclosed |
| EP-1044972-A1 | 5,6,7-TRINOR-4,8-INTER-m-PHENYLENE PGI2 DERIVATIVE AND DRUGS CONTAINING THE SAME | TORAY INDUSTRIES, INC. (JP) | 2000-10-18 | — | — | EP | disclosed |