Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | ELANE | P08246 | 1/20 | 0.68 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.66 |
| ▸ | TERT | O14746 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | APP | P05067 | 1/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057928 | 0.89 | ACHE (0.76) | ALDH1A1MAPTCYP3A4MAPK1USP2 | |
| SCHEMBL8000230 | 0.88 | APP (0.81) | MAPTCYP1B1KDM4EKMT2APOLB | |
| Isowogonin SCHEMBL28012275 | 0.86 | ACHE (0.79) | ALDH1A1MAPTCYP3A4CYP1B1KDM4E | |
| SCHEMBL5163188 | 0.85 | TERT (0.70) | ALDH1A1MAPTCYP3A4MAPK1USP2 | |
| SCHEMBL25383379 | 0.84 | ALDH1A1 (0.82) | ALDH1A1MAPTCYP3A4MAPK1USP2 | |
| SCHEMBL30954258 | 0.82 | MEN1 (0.71) | ALDH1A1MAPTCYP1B1TERTKDM4E | |
| SCHEMBL1764664 | 0.81 | ALDH1A1 (0.86) | ALDH1A1MAPTCYP3A4MAPK1USP2 | |
| 5-Demethylnobiletin SCHEMBL31237479 | 0.81 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4MAPK1USP2 | |
| SCHEMBL25225757 | 0.81 | ALDH1A1 (0.82) | ALDH1A1MAPTCYP3A4MAPK1USP2 | |
| SCHEMBL30956242 | 0.81 | ALDH1A1 (0.70) | ALDH1A1MAPTCYP3A4MAPK1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6555523-B1 | Such as 3',4'-diacetoxy-5,6,7-trimethoxyflavone or naringin in the treatment HIV, picornavirus, and/or respiratory virus | CASCADE ESTATES LTD. (MU) | 2003-04-29 | — | — | US | disclosed |
| EP-1223928-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | Prendergast, Patrick Thomas (IE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001003681-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | PRENDERGAST PATRICK T (IE) | 2001-01-18 | — | — | WO | disclosed |