Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 12/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5682208 | 0.79 | AKR1C3 (0.40) | SIRT2PTGS1AKR1C3AKR1C2ACSS2 | |
| SCHEMBL5749684 | 0.75 | AKR1C3 (0.37) | SIRT2PTGS1AKR1C3AKR1C2ACSS2 | |
| SCHEMBL5748920 | 0.75 | PTGS2 (0.38) | SIRT2PTGS1AKR1C3AKR1C2ACSS2 | |
| SCHEMBL7817690 | 0.74 | AKR1C3 (0.36) | SIRT2PTGS1AKR1C3AKR1C2ACSS2 | |
| SCHEMBL7809863 | 0.74 | PTGS2 (0.36) | SIRT2PTGS1AKR1C3AKR1C2ACSS2 | |
| SCHEMBL7817687 | 0.73 | LMNA (0.36) | SIRT2PTGS1AKR1C3AKR1C2ACSS2 | |
| SCHEMBL4025463 | 0.73 | CYP11B1 (0.39) | SIRT2 | |
| SCHEMBL7826102 | 0.72 | SRC (0.36) | SIRT2CYP19A1ACSS2 | |
| SCHEMBL7818117 | 0.72 | SIRT2 (0.44) | SIRT2CYP19A1 | |
| SCHEMBL14249050 | 0.72 | SIRT2 (0.40) | SIRT2ACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6573289-B1 | Naphthalene derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-06-03 | — | — | US | disclosed |