Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 8/20 | 0.46 |
| ▸ | THRA | P10827 | 6/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5388979 | 0.76 | THRB (0.53) | THRBTHRASMN1; SMN2TP53MAPT | |
| Dichloroacetic Acid SCHEMBL7173116 | 0.73 | THRA (0.56) | THRBTHRAMAPTALDH1A1POLB | |
| SCHEMBL5381973 | 0.70 | THRB (0.48) | THRBTHRASMN1; SMN2TP53MAPT | |
| SCHEMBL5385273 | 0.69 | THRB (0.54) | THRBTHRASMN1; SMN2TP53MAPT | |
| SCHEMBL5388975 | 0.68 | THRB (0.65) | THRBTHRASMN1; SMN2TP53MAPT | |
| SCHEMBL5385275 | 0.65 | THRA (0.58) | THRBTHRAMAPTALDH1A1POLB | |
| SCHEMBL7185064 | 0.65 | PGR (0.37) | THRBRXRANR4A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL5388467 | 0.64 | THRB (0.72) | THRBTHRAHTTMTNR1BKDM4E | |
| SCHEMBL5392866 | 0.63 | THRA (1.00) | THRBTHRA | |
| SCHEMBL28503676 | 0.63 | KDM4E (0.56) | RXRANR4A2SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296936-A1 | THYROID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE TREATMENT OF DISORDERS INFLUENCED BY THYROID HORMONES | KARO BIO AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001098256-A1 | THYROID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE TREATMENT OF DISORDERS INFLUENCED BY THYROID HORMONES | KARO BIO AB (SE) | 2001-12-27 | — | — | WO | disclosed |