Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RHOA | P61586 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5394461 | 0.68 | AKR1B1 (0.37) | KDM4ESMN1; SMN2ESR1ESR2MEN1 | |
| SCHEMBL4354279 | 0.67 | MEN1 (0.37) | PGRALDH1A1POLBTHRBMEN1 | |
| SCHEMBL7174069 | 0.65 | THRB (0.46) | KDM4EALDH1A1SMN1; SMN2POLBRXRA | |
| SCHEMBL28503676 | 0.64 | KDM4E (0.56) | KDM4EALDH1A1SMN1; SMN2RXRANR4A2 | |
| SCHEMBL5389009 | 0.62 | THRA (0.39) | PGRALOX15HSD17B10THRBKMT2A | |
| SCHEMBL15730582 | 0.61 | MAOA (0.51) | PGRALDH1A1POLB | |
| SCHEMBL28498982 | 0.61 | THRB (0.64) | KDM4EALDH1A1SMN1; SMN2PIM2HPGD | |
| SCHEMBL27684130 | 0.61 | THRB (0.64) | KDM4EALDH1A1SMN1; SMN2PIM2HPGD | |
| SCHEMBL6913211 | 0.61 | PGR (0.36) | PGRPOLBMAPK1THRB | |
| SCHEMBL8937421 | 0.60 | KDM4E (0.70) | KDM4EALDH1A1SMN1; SMN2HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296936-A1 | THYROID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE TREATMENT OF DISORDERS INFLUENCED BY THYROID HORMONES | KARO BIO AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001098256-A1 | THYROID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE TREATMENT OF DISORDERS INFLUENCED BY THYROID HORMONES | KARO BIO AB (SE) | 2001-12-27 | — | — | WO | disclosed |