SCHEMBL7175290

SCHEMBL7175290

Cc1cccc(C)c1C(=O)P(=O)(C(=O)c1c(C(F)(F)F)cccc1C(F)(F)F)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.39
GAA P10253 3/20 0.39
NPSR1 Q6W5P4 3/20 0.39
KDM4E B2RXH2 2/20 0.39
ATM Q13315 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
TAS2R14 Q9NYV8 2/20 0.38
ALOX12 P18054 2/20 0.38
LMNA P02545 1/20 0.36
RIPK1 Q13546 1/20 0.36
ACP3 P15309 1/20 0.35
RORC P51449 3/20 0.35
KCNK3 O14649 2/20 0.35
KCNK9 Q9NPC2 2/20 0.35
CTSA P10619 1/20 0.34
TYK2 P29597 1/20 0.34
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7180976 0.91 TYK2 (0.43) ALDH1A1RORCTYK2MAPT
SCHEMBL7186785 0.91 LMNA (0.44) ALDH1A1GAANPSR1KDM4EATM
SCHEMBL7180481 0.91 TAS2R14 (0.39) ALDH1A1GAANPSR1KDM4EATM
SCHEMBL7182459 0.90 CTSA (0.36) ALDH1A1GAANPSR1KDM4EATM
SCHEMBL7181415 0.89 TAS2R14 (0.41) ALDH1A1GAANPSR1KDM4ETAS2R14
SCHEMBL7180834 0.88 NPSR1 (0.37) GAANPSR1TAS2R14LMNARIPK1
SCHEMBL7180917 0.88 TAS2R14 (0.39) ALDH1A1GAANPSR1KDM4EATM
SCHEMBL246249 0.86 L3MBTL1 (0.41) ALDH1A1GAAKDM4ETDP1ACP3
SCHEMBL7179453 0.85 TAS2R14 (0.37) ALDH1A1GAANPSR1KDM4EATM
SCHEMBL7174860 0.84 TYK2 (0.40) ALDH1A1NPSR1ALOX12LMNARORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ALDH1A1 3416/4885GAA 4753/4885NPSR1 2669/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ALDH1A1 3984/4885GAA 4793/4885NPSR1 3007/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.