Sugi Predict

Sugi Predict / Compounds / SCHEMBL7180917

SCHEMBL7180917

SCHEMBL7180917

Cc1cc(C)c(C)c(C(=O)P(=O)(C(=O)c2c(C(F)(F)F)cccc2C(F)(F)F)c2ccccc2)c1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TAS2R14 Q9NYV8 2/20 0.39
▸ PGK1 P00558 1/20 0.36
▸ PGK2 P07205 1/20 0.36
▸ KCNK3 O14649 2/20 0.35
▸ KCNK9 Q9NPC2 2/20 0.35
▸ RIPK1 Q13546 1/20 0.34
▸ LMNA P02545 3/20 0.34
▸ GAA P10253 2/20 0.34
▸ ALDH1A1 P00352 4/20 0.34
▸ NPSR1 Q6W5P4 4/20 0.34
▸ ALOX12 P18054 3/20 0.34
▸ HTT P42858 2/20 0.34
▸ MAPT P10636 2/20 0.34
▸ CYP1A2 P05177 2/20 0.34
▸ CYP2C19 P33261 2/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ ATM Q13315 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ PLA2G1B P04054 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7179453 0.92 TAS2R14 (0.37) TAS2R14PGK1PGK2KCNK3KCNK9
SCHEMBL7181415 0.91 TAS2R14 (0.41) TAS2R14KCNK3KCNK9LMNAGAA
SCHEMBL7180481 0.90 TAS2R14 (0.39) TAS2R14KCNK3KCNK9RIPK1LMNA
SCHEMBL7175290 0.88 ALDH1A1 (0.39) TAS2R14KCNK3KCNK9RIPK1LMNA
SCHEMBL7186785 0.87 LMNA (0.44) TAS2R14KCNK3KCNK9RIPK1LMNA
SCHEMBL7735676 0.85 CTSS (0.35) TAS2R14LMNAGAAALDH1A1HTT
SCHEMBL7180834 0.85 NPSR1 (0.37) TAS2R14PGK1PGK2KCNK3KCNK9
SCHEMBL7178032 0.83 POLB (0.36) KCNK3KCNK9LMNAGAAALDH1A1
SCHEMBL7180976 0.82 TYK2 (0.43) ALDH1A1MAPTCYP2C9KMT2ACYP3A4
SCHEMBL7182459 0.81 CTSA (0.36) TAS2R14GAAALDH1A1NPSR1ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 TAS2R14 2184/4885PGK1 3228/4885PGK2 3415/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 TAS2R14 2410/4885PGK1 3433/4885PGK2 3445/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.