Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | RGS12 | O14924 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8467020 | 0.82 | ALDH1A1 (0.49) | HPGDGAAMAPTTSHRNFKB1 | |
| SCHEMBL28475391 | 0.81 | RXRA (0.51) | RXRARXRBKDM4EHPGDHSD17B10 | |
| SCHEMBL9408593 | 0.78 | CYP4F2 (0.42) | RXRARXRBHSD17B10GAAMAPT | |
| Hydrochloric Acid SCHEMBL17653926 | 0.78 | RXRA (0.50) | RXRARXRBKDM4EHPGDHSD17B10 | |
| SCHEMBL154429 | 0.77 | KDM4E (0.55) | KDM4EHPGDHSD17B10GAAMAPT | |
| SCHEMBL28486097 | 0.77 | RXRA (0.48) | RXRARXRBKDM4EHPGDHSD17B10 | |
| SCHEMBL17653880 | 0.77 | GAA (0.64) | RXRARXRBKDM4EHPGDHSD17B10 | |
| SCHEMBL7176123 | 0.77 | ALDH1A1 (0.49) | RXRARXRBKDM4EHPGDHSD17B10 | |
| SCHEMBL283594 | 0.77 | KDM4E (0.50) | RXRARXRBKDM4EHPGDHSD17B10 | |
| SCHEMBL23665805 | 0.76 | RXRA (0.47) | RXRARXRBKDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645973-B1 | Heterocyclic amines such as 1-carboxymethyl-4-(4-chlorophenyl) spiro(2H-1-benzopyran-2,4'-piperidine)hydrochloride used for therapy of nervous system disorders; Alzheimer's, Parkinson's and Huntington's disease | AKZO NOBEL (NL) | 2003-11-11 | — | — | US | disclosed |