Sugi Predict

Sugi Predict / Compounds / SCHEMBL7175607

SCHEMBL7175607

SCHEMBL7175607

COc1cccc(Cl)c1C(=O)Pc1ccc(OCC(C)C)cc1C.[LiH]

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ GAA P10253 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ HDAC8 Q9BY41 1/20 0.37
▸ KMT2A Q03164 3/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ PKM P14618 1/20 0.37
▸ XDH P47989 1/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.36
▸ ROCK2 O75116 1/20 0.35
▸ ROCK1 Q13464 1/20 0.35
▸ MAOA P21397 1/20 0.35
▸ MAOB P27338 1/20 0.35
▸ FOS P01100 1/20 0.35
▸ JUN P05412 1/20 0.35
▸ FFAR1 O14842 1/20 0.35
▸ MCL1 Q07820 1/20 0.35
▸ GHSR Q92847 1/20 0.35
▸ SIRT2 Q8IXJ6 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7189092 0.94 XDH (0.39) MAPTKMT2AMEN1XDHSMN1; SMN2
SCHEMBL7176019 0.94 KMT2A (0.41) MAPTALDH1A1GAAKMT2AMEN1
SCHEMBL7188974 0.91 FOS (0.38) MAPTALDH1A1KMT2AXDHROCK2
SCHEMBL7184492 0.90 KMT2A (0.39) MAPTALDH1A1KMT2AMEN1PKM
SCHEMBL7181389 0.90 ALDH1A1 (0.38) MAPTALDH1A1GAAL3MBTL1KMT2A
Lithium SCHEMBL7188985 0.88 SLC16A3 (0.36) MAPTALDH1A1KMT2AXDHROCK2
SCHEMBL7174867 0.88 SMN1; SMN2 (0.46) MAPTALDH1A1GAAL3MBTL1HDAC8
SCHEMBL7182853 0.87 PNLIP (0.36) MAPTALDH1A1GAAL3MBTL1SMN1; SMN2
SCHEMBL7182596 0.87 MAPT (0.43) MAPTALDH1A1GAAL3MBTL1KMT2A
SCHEMBL7179035 0.86 MAPT (0.40) MAPTALDH1A1GAAL3MBTL1HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 MAPT 4870/4885ALDH1A1 3416/4885GAA 4753/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 MAPT 4859/4885ALDH1A1 3984/4885GAA 4793/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.