Sugi Predict

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SCHEMBL7175877

SCHEMBL7175877

Cc1cc(C)c(C(=O)P(=O)(C(=O)c2c(C)cc(C(C)(C)C)cc2C)c2ccccc2)c(C)c1C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.37
▸ LMNA P02545 2/20 0.36
▸ MEN1 O00255 4/20 0.34
▸ KMT2A Q03164 4/20 0.34
▸ KDM4E B2RXH2 2/20 0.34
▸ HPGD P15428 1/20 0.34
▸ RXRB P28702 3/20 0.34
▸ MAPT P10636 2/20 0.33
▸ KCNK9 Q9NPC2 1/20 0.33
▸ PPARG P37231 2/20 0.33
▸ PPARA Q07869 1/20 0.33
▸ NR1H4 Q96RI1 1/20 0.33
▸ GAA P10253 2/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ TSHR P16473 2/20 0.33
▸ RXRA P19793 2/20 0.32
▸ TP53 P04637 1/20 0.32
▸ THRB P10828 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7190426 0.93 ALDH1A1 (0.38) ALDH1A1LMNAMEN1KMT2AKDM4E
SCHEMBL7189042 0.92 MEN1 (0.35) ALDH1A1LMNAMEN1KMT2AKDM4E
SCHEMBL7179675 0.92 LMNA (0.37) ALDH1A1LMNAMEN1KMT2AKDM4E
SCHEMBL7187514 0.92 LMNA (0.40) ALDH1A1LMNAMEN1KMT2ARXRB
SCHEMBL7181616 0.90 KMT2A (0.36) ALDH1A1LMNAMEN1KMT2AKDM4E
SCHEMBL7182418 0.89 LMNA (0.39) ALDH1A1LMNAMEN1KMT2AKDM4E
SCHEMBL7177289 0.87 L3MBTL1 (0.34) ALDH1A1LMNAMEN1KMT2AKDM4E
SCHEMBL7180033 0.87 LMNA (0.35) ALDH1A1LMNAMEN1KMT2AHPGD
SCHEMBL7180182 0.87 LMNA (0.40) ALDH1A1LMNAMEN1KMT2AKDM4E
SCHEMBL7182360 0.87 TP53 (0.39) ALDH1A1LMNAMEN1KMT2ARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ALDH1A1 3416/4885LMNA 3241/4885MEN1 2312/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ALDH1A1 3984/4885LMNA 3247/4885MEN1 2263/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.