Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 3/20 | 0.46 |
| ▸ | MMP3 | P08254 | 3/20 | 0.46 |
| ▸ | MMP9 | P14780 | 3/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7172740 | 0.92 | MMP3 (0.52) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL7174678 | 0.91 | MMP1 (0.47) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL7177674 | 0.89 | MMP1 (0.46) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL7172633 | 0.87 | FCER2 (0.41) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL7173112 | 0.87 | MMP1 (0.44) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL7192046 | 0.82 | MMP3 (0.52) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL7173324 | 0.81 | SCN9A (0.43) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL7170041 | 0.81 | MMP3 (0.52) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL7177702 | 0.79 | MMP3 (0.50) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL7170096 | 0.78 | FCER2 (0.50) | MMP1MMP3MMP9MMP2MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576628-B1 | Matrix metalloprotease inhibitors; arthritis, corneal ulcers, arteriosclerosis | ROCHE DIAGNOSTICS GMBH (DE) | 2003-06-10 | — | — | US | disclosed |
| EP-1005449-B1 | 3-ARYL-SUCCINAMIDO-HYDROXAMIC ACIDS, METHODS FOR PRODUCING SAID ACIDS AND MEDICAMENTS CONTAINING THE SAME | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-30 | — | — | EP | disclosed |
| EP-0897908-A1 | 3-Aryl-succinamido-hydroxamic acids, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1999-02-24 | — | — | EP | disclosed |