Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 4/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | MIF | P14174 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 6/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL74774 | 0.85 | CDK2 (0.53) | IRAK4CDK2CDK1CDK4MIF | |
| SCHEMBL72956 | 0.85 | CDK2 (0.60) | IRAK4CDK2CDK1CDK4MIF | |
| SCHEMBL72363 | 0.83 | IRAK4 (0.61) | IRAK4CDK2CDK1CDK4MIF | |
| SCHEMBL3592576 | 0.82 | KDR (0.63) | FLT3KDRFGFR3GABRG2GABRB3 | |
| SCHEMBL73961 | 0.80 | IRAK4 (0.52) | IRAK4CDK2CDK1CDK4MIF | |
| SCHEMBL73095 | 0.78 | PKM (0.53) | IRAK4CDK2CDK1CDK4MIF | |
| SCHEMBL2789410 | 0.78 | KDR (0.56) | FLT3KDR | |
| SCHEMBL73153 | 0.75 | CDK2 (0.58) | IRAK4CDK2CDK1CDK4MIF | |
| SCHEMBL73956 | 0.75 | CDK2 (0.48) | IRAK4CDK2CDK1CDK4MIF | |
| Formic Acid SCHEMBL73159 | 0.75 | IRAK4 (0.47) | IRAK4CDK2CDK1CDK4MIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |