Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 6/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.50 |
| ▸ | MIF | P14174 | 1/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL72363 | 0.88 | IRAK4 (0.61) | CDK2CDK1CDK4KDRMIF | |
| SCHEMBL72956 | 0.87 | CDK2 (0.60) | CDK2CDK1CDK4KDRGABRG2 | |
| SCHEMBL71795 | 0.85 | IRAK4 (0.53) | CDK2CDK1CDK4KDRGABRG2 | |
| SCHEMBL29822550 | 0.81 | KDR (0.68) | CDK2KDRGABRG2GABRB3GABRA3 | |
| SCHEMBL73095 | 0.80 | PKM (0.53) | CDK2CDK1CDK4KDRMIF | |
| SCHEMBL73153 | 0.80 | CDK2 (0.58) | CDK2CDK1CDK4KDRMIF | |
| SCHEMBL73956 | 0.77 | CDK2 (0.48) | CDK2CDK1CDK4KDRMIF | |
| SCHEMBL73961 | 0.77 | IRAK4 (0.52) | CDK2CDK1CDK4KDRMIF | |
| SCHEMBL23241872 | 0.77 | CDK2 (0.72) | CDK2CDK1CDK4IRAK4PKM | |
| SCHEMBL73262 | 0.76 | FGFR3 (0.53) | CDK2CDK1CDK4KDRMIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |