Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.58 |
| ▸ | CDK1 | P06493 | 1/20 | 0.58 |
| ▸ | CDK4 | P11802 | 1/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.51 |
| ▸ | TUBB | P07437 | 4/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.51 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.51 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.51 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.51 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL72363 | 0.88 | IRAK4 (0.61) | CDK2CDK1CDK4PIK3CAIRAK4 | |
| SCHEMBL15757448 | 0.81 | FLT3 (0.65) | PIK3CATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL74774 | 0.80 | CDK2 (0.53) | CDK2CDK1CDK4PIK3CAIRAK4 | |
| SCHEMBL72956 | 0.79 | CDK2 (0.60) | CDK2CDK1CDK4PIK3CAIRAK4 | |
| SCHEMBL73232 | 0.77 | CDK2 (0.52) | CDK2CDK1CDK4PIK3CAIRAK4 | |
| SCHEMBL73280 | 0.76 | PIK3CA (0.50) | PIK3CAMIFKDRFLT3PKM | |
| SCHEMBL12848505 | 0.75 | PIK3CA (0.65) | PIK3CATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL71795 | 0.75 | IRAK4 (0.53) | CDK2CDK1CDK4PIK3CAIRAK4 | |
| SCHEMBL1684661 | 0.75 | CDK2 (0.67) | CDK2CDK1CDK4PIK3CATUBB4A | |
| SCHEMBL72789 | 0.75 | FYN (0.63) | CDK2KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |