Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 6/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3587763 | 0.86 | KDR (0.60) | CDK2FLT3KDRFGFR3PRMT5 | |
| SCHEMBL13407687 | 0.85 | GABRG2 (0.53) | FLT3KDRFGFR3PRMT5WDR77 | |
| SCHEMBL72363 | 0.82 | IRAK4 (0.61) | CDK2CDK1CDK4MIFIRAK4 | |
| SCHEMBL72956 | 0.79 | CDK2 (0.60) | CDK2CDK1CDK4MIFIRAK4 | |
| SCHEMBL74774 | 0.77 | CDK2 (0.53) | CDK2CDK1CDK4MIFIRAK4 | |
| SCHEMBL73262 | 0.76 | FGFR3 (0.53) | CDK2CDK1CDK4MIFIRAK4 | |
| SCHEMBL13407688 | 0.75 | KDR (0.54) | FLT3KDRFGFR3 | |
| SCHEMBL71795 | 0.75 | IRAK4 (0.53) | CDK2CDK1CDK4MIFIRAK4 | |
| SCHEMBL73153 | 0.74 | CDK2 (0.58) | CDK2CDK1CDK4MIFIRAK4 | |
| SCHEMBL73961 | 0.74 | IRAK4 (0.52) | CDK2CDK1CDK4MIFIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |