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SCHEMBL7180176

SCHEMBL7180176

Cc1cc(C)c(C(=O)C(C(=O)OC(C)C)c2ccccc2)c(C)c1.O=[PH3]

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 2/20 0.38
▸ HTT P42858 3/20 0.37
▸ GAA P10253 3/20 0.37
▸ LMNA P02545 2/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ MMP8 P22894 1/20 0.37
▸ NPSR1 Q6W5P4 3/20 0.36
▸ SLC6A2 P23975 2/20 0.35
▸ SLC6A4 P31645 2/20 0.35
▸ SLC6A3 Q01959 2/20 0.35
▸ SRC P12931 1/20 0.35
▸ TSHR P16473 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ POLB P06746 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ KEAP1 Q14145 1/20 0.34
▸ NFE2L2 Q16236 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ PDCD1 Q15116 1/20 0.34
▸ CD274 Q9NZQ7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27486287 0.96 L3MBTL1 (0.39) L3MBTL1HTTGAALMNAALDH1A1
SCHEMBL7189261 0.89 L3MBTL1 (0.47) L3MBTL1HTTGAAALDH1A1MMP8
SCHEMBL7180641 0.88 L3MBTL1 (0.36) L3MBTL1HTTGAALMNAALDH1A1
SCHEMBL7181316 0.87 L3MBTL1 (0.37) L3MBTL1HTTGAALMNAALDH1A1
SCHEMBL7177876 0.86 KMT2A (0.46) L3MBTL1LMNAALDH1A1MMP8NPSR1
SCHEMBL27483933 0.86 L3MBTL1 (0.47) L3MBTL1HTTGAALMNAALDH1A1
SCHEMBL7183564 0.85 MMP8 (0.54) L3MBTL1GAAMMP8SLC6A2SLC6A4
SCHEMBL7187729 0.84 ALDH1A1 (0.43) L3MBTL1LMNAALDH1A1MMP8NPSR1
SCHEMBL7189399 0.83 L3MBTL1 (0.38) L3MBTL1HTTGAALMNAALDH1A1
SCHEMBL14781389 0.82 SRC (0.47) L3MBTL1HTTGAALMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 L3MBTL1 302/4885HTT 2802/4885GAA 4753/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 L3MBTL1 126/4885HTT 2393/4885GAA 4793/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.