Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | JAK3 | P52333 | 4/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7180238 | 1.00 | HSD11B1 (0.39) | HSD11B1JAK2JAK3IDO1CYP2C9 | |
| SCHEMBL7191692 | 0.83 | ALDH1A1 (0.49) | HSD11B1JAK2JAK3CYP2C9CYP2C19 | |
| SCHEMBL7191736 | 0.81 | TNKS (0.54) | HSD11B1JAK2JAK3TNKSPDE4B | |
| SCHEMBL7191729 | 0.81 | TNKS (0.54) | HSD11B1JAK2JAK3TNKSPDE4B | |
| SCHEMBL7178530 | 0.77 | JAK2 (0.39) | HSD11B1JAK2JAK3CYP2C9CYP2C19 | |
| SCHEMBL7178523 | 0.77 | JAK2 (0.39) | HSD11B1JAK2JAK3CYP2C9CYP2C19 | |
| SCHEMBL21811053 | 0.77 | HSD11B1 (0.45) | HSD11B1JAK2JAK3CYP2C9CYP2C19 | |
| SCHEMBL21811052 | 0.77 | HSD11B1 (0.45) | HSD11B1JAK2JAK3CYP2C9CYP2C19 | |
| SCHEMBL7183866 | 0.77 | HSD11B1 (0.47) | HSD11B1MAPTKDM4E | |
| SCHEMBL20468291 | 0.71 | PRKDC (0.43) | HSD11B1JAK2JAK3CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |