Sugi Predict

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SCHEMBL7180464

SCHEMBL7180464

Cc1cc(C)c(C(=O)P(=O)(C(=O)c2c(C)c(C)cc(C)c2C)c2ccccc2)c(C)c1C

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 6/20 0.34
▸ MEN1 O00255 5/20 0.34
▸ NPC1 O15118 2/20 0.33
▸ RAB9A P51151 2/20 0.33
▸ CA2 P00918 1/20 0.33
▸ CA4 P22748 1/20 0.33
▸ CA5A P35218 1/20 0.33
▸ USP2 O75604 1/20 0.33
▸ ESR1 P03372 1/20 0.33
▸ HSD17B10 Q99714 2/20 0.32
▸ KDM4E B2RXH2 2/20 0.32
▸ GFER P55789 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ HPGD P15428 1/20 0.32
▸ CRHBP P24387 1/20 0.32
▸ CRHR2 Q13324 1/20 0.32
▸ MAPT P10636 2/20 0.32
▸ GAA P10253 2/20 0.32
▸ TP53 P04637 1/20 0.32
▸ ALOX15 P16050 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7174855 0.97 GFER (0.35) KMT2AMEN1NPC1RAB9ACA2
SCHEMBL7181616 0.97 KMT2A (0.36) KMT2AMEN1NPC1RAB9ACA2
SCHEMBL7181615 0.94 KMT2A (0.33) KMT2AMEN1NPC1RAB9ACA2
SCHEMBL7180033 0.91 LMNA (0.35) KMT2AMEN1NPC1RAB9AALDH1A1
SCHEMBL7177289 0.91 L3MBTL1 (0.34) KMT2AMEN1NPC1RAB9ACA2
SCHEMBL7188516 0.89 LMNA (0.37) KMT2AMEN1NPC1RAB9AALDH1A1
SCHEMBL7184875 0.88 ALDH1A1 (0.33) KMT2AMEN1NPC1RAB9ACA2
SCHEMBL7178032 0.88 POLB (0.36) KMT2AMEN1NPC1RAB9ACA2
SCHEMBL7175604 0.87 MAPT (0.36) KMT2AMEN1RAB9AUSP2ALDH1A1
SCHEMBL7182227 0.87 MEN1 (0.33) KMT2AMEN1NPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 KMT2A 1586/4885MEN1 2312/4885NPC1 772/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 KMT2A 956/4885MEN1 2263/4885NPC1 872/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.