Sugi Predict

Sugi Predict / Compounds / SCHEMBL7180840

SCHEMBL7180840

SCHEMBL7180840

Cc1cc(C(C)(C)C)cc(C)c1C(=O)[PH](=O)c1c(C(F)(F)F)ccc(C(=O)c2ccccc2)c1C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RXRB P28702 4/20 0.36
▸ TDP1 Q9NUW8 1/20 0.36
▸ ABCC9 O60706 4/20 0.34
▸ ABCC8 Q09428 4/20 0.34
▸ KCNJ11 Q14654 4/20 0.34
▸ KCNJ8 Q15842 4/20 0.34
▸ NR1H2 P55055 1/20 0.34
▸ NR1H3 Q13133 1/20 0.34
▸ RXRA P19793 3/20 0.34
▸ LMNA P02545 2/20 0.33
▸ ELANE P08246 1/20 0.33
▸ ACHE P22303 1/20 0.33
▸ MEN1 O00255 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ CYP1A2 P05177 1/20 0.32
▸ CYP2C9 P11712 1/20 0.32
▸ HPGD P15428 1/20 0.32
▸ CYP2C19 P33261 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7188654 0.91 NR1H2 (0.35) ABCC9ABCC8KCNJ11KCNJ8NR1H2
SCHEMBL7180611 0.89 NR1H2 (0.39) ABCC9ABCC8KCNJ11KCNJ8NR1H2
SCHEMBL7730579 0.87 NR1H2 (0.34) ABCC9ABCC8KCNJ11KCNJ8NR1H2
SCHEMBL7182363 0.82 TDP1 (0.39) RXRBTDP1RXRALMNAELANE
SCHEMBL7187986 0.82 RORC (0.40) NR1H2NR1H3LMNAALDH1A1CYP2C9
SCHEMBL7183901 0.81 LMNA (0.37) RXRBTDP1RXRALMNAACHE
SCHEMBL7182423 0.80 ALDH1A1 (0.37) RXRBTDP1RXRALMNAELANE
SCHEMBL7182189 0.80 RORC (0.39) NR1H2NR1H3LMNAALDH1A1CYP2C9
SCHEMBL7177062 0.79 MAPT (0.42) NR1H2NR1H3LMNAELANEMEN1
SCHEMBL7175334 0.79 TP53 (0.36) RXRBTDP1LMNAELANEALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 RXRB 3027/4885TDP1 4234/4885ABCC9 1203/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 RXRB 3240/4885TDP1 4275/4885ABCC9 1824/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.