Sugi Predict

Sugi Predict / Compounds / SCHEMBL7182363

SCHEMBL7182363

SCHEMBL7182363

Cc1cc(C(C)(C)C)cc(C)c1C(=O)[PH](=O)c1c(C)ccc(C(=O)c2ccccc2)c1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 1/20 0.39
▸ LMNA P02545 2/20 0.38
▸ RXRB P28702 3/20 0.36
▸ ELANE P08246 2/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ ALDH1A1 P00352 4/20 0.35
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ RXRA P19793 2/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ USP2 O75604 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ KEAP1 Q14145 1/20 0.34
▸ NFE2L2 Q16236 1/20 0.34
▸ PTGS2 P35354 1/20 0.34
▸ PPARG P37231 1/20 0.34
▸ NPC1 O15118 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ PGR P06401 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7180492 0.89 NPSR1 (0.40) LMNANPSR1ALDH1A1MEN1KMT2A
SCHEMBL7182423 0.88 ALDH1A1 (0.37) TDP1LMNARXRBELANENPSR1
SCHEMBL7187402 0.86 LMNA (0.37) TDP1LMNARXRBNPSR1ALDH1A1
SCHEMBL7182859 0.85 NPSR1 (0.36) LMNANPSR1ALDH1A1MEN1KMT2A
SCHEMBL7190429 0.85 LMNA (0.38) TDP1LMNARXRBALDH1A1RXRA
SCHEMBL7175881 0.83 LMNA (0.36) TDP1LMNARXRBALDH1A1RXRA
SCHEMBL7200655 0.83 MEN1 (0.37) TDP1LMNARXRBELANEALDH1A1
SCHEMBL7175334 0.83 TP53 (0.36) TDP1LMNARXRBELANEALDH1A1
SCHEMBL7180840 0.82 RXRB (0.36) TDP1LMNARXRBELANEALDH1A1
SCHEMBL7187668 0.81 TDP1 (0.35) TDP1LMNARXRBELANERXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 TDP1 4234/4885LMNA 3241/4885RXRB 3027/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 TDP1 4275/4885LMNA 3247/4885RXRB 3240/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.