SCHEMBL718187

SCHEMBL718187

Nc1ccc(C(c2ccc(N)c(S)c2)(C(F)(F)F)C(F)(F)F)cc1S

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.40
ESR2 Q92731 1/20 0.40
ALDH1A1 P00352 4/20 0.35
KDM4E B2RXH2 3/20 0.35
PKM P14618 1/20 0.35
HPGD P15428 1/20 0.35
HSD17B10 Q99714 1/20 0.35
KIF11 P52732 2/20 0.34
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
MEN1 O00255 1/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
GFER P55789 1/20 0.33
KMT2A Q03164 1/20 0.33
PTPN5 P54829 2/20 0.32
CFTR P13569 1/20 0.32
BACE1 P56817 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8510672 0.94 ESR1 (0.36) ESR1ESR2ALDH1A1KDM4EPKM
SCHEMBL29464084 0.85 ESR1 (0.41) ESR1ESR2ALDH1A1KDM4EPKM
SCHEMBL295863 0.85 ESR1 (0.41) ESR1ESR2ALDH1A1KDM4EPKM
SCHEMBL30532274 0.85 ALDH1A1 (0.47) ALDH1A1KDM4EPKMHPGDHSD17B10
SCHEMBL2788945 0.85 ALDH1A1 (0.47) ALDH1A1KDM4EPKMHPGDHSD17B10
SCHEMBL14934147 0.83 ALDH1A1 (0.35) ALDH1A1KDM4EPKMHPGDHSD17B10
Hydrochloric Acid SCHEMBL4183751 0.83 ALDH1A1 (0.46) ALDH1A1KDM4EPKMHPGDHSD17B10
SCHEMBL6757387 0.83 ALDH1A1 (0.37) ALDH1A1KDM4EPKMHPGDHSD17B10
SCHEMBL8509753 0.81 NR4A1 (0.41) ESR1ESR2ALDH1A1HPGDTSHR
SCHEMBL296596 0.80 ESR1 (0.44) ESR1ESR2ALDH1A1KDM4EPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0712842-B1 Bisaminothiophenol compound, process for producing the same and curing agent for fluorine-containing elastomer comprising the same NIPPON MEKTRON KK (JP) 1998-12-30 EP claimed
US-5688872-A VULCANIZABLE FLUOROPOLYMER ELASTOMERS NIPPON MEKTRON, LIMITED (JP) 1997-11-18 US claimed
US-5672758-A FOR VULCANIZING ELASTOMERIC FLUOROPOLYMERS CONTAINING A CROSSLINKABLE CYANO GROUP NIPPON MEKTRON, LIMITED (JP) 1997-09-30 US claimed
EP-0712842-A1 Bisaminothiophenol compound, process for producing the same and curing agent for fluorine-containing elastomer comprising the same NIPPON MEKTRON, LTD. (JP) 1996-05-22 EP claimed
JP-8143535-A None JP disclosed
US-8536299-B2 Rigid-rod copolymer compositions and the polymeric fibers fabricated from those compositions for enhanced flame resistance UNIVERSITY OF DAYTON (US) 2013-09-17 US disclosed
US-8216727-B2 Aromatic hydrocarbon based proton exchange membrane and direct methanol fuel cell using same TOYO BOSEKI KABUSHIKI KAISHA (JP) 2012-07-10 US disclosed
US-20120052411-A9 AROMATIC HYDROCARBON BASED PROTON EXCHANGE MEMBRANE AND DIRECT METHANOL FUEL CELL USING SAME TOYO BOSEKI KABUSHIKI KAISHA (JP) 2012-03-01 US disclosed
US-7799893-B2 Polybenzazole block copolymer SOLVAY (SOCIETE ANONYME) (BE) 2010-09-21 US disclosed
WO-2010077565-A2 RIGID-ROD COPOLYMER COMPOSITIONS AND THE POLYMERIC FIBERS FABRICATED FROM THOSE COMPOSITIONS FOR ENHANCED FLAME RESISTANCE UNIVERSITY OF DAYTON (US) 2010-07-08 WO disclosed
US-20100145004-A1 RIGID-ROD COPOLYMER COMPOSITIONS AND THE POLYMERIC FIBERS FABRICATED FROM THOSE COMPOSITIONS FOR ENHANCED FLAME RESISTANCE UNIVERSITY OF DAYTON (US) 2010-06-10 US disclosed
EP-1812497-B1 POLYBENZAZOLE BLOCK COPOLYMER SOLVAY (BE) 2009-06-17 EP disclosed
US-5688872-A VULCANIZABLE FLUOROPOLYMER ELASTOMERS NIPPON MEKTRON, LIMITED (JP) 1997-11-18 US disclosed
US-5688872-A VULCANIZABLE FLUOROPOLYMER ELASTOMERS NIPPON MEKTRON, LIMITED (JP) 1997-11-18 US disclosed
US-5672758-A FOR VULCANIZING ELASTOMERIC FLUOROPOLYMERS CONTAINING A CROSSLINKABLE CYANO GROUP NIPPON MEKTRON, LIMITED (JP) 1997-09-30 US disclosed
US-5672758-A FOR VULCANIZING ELASTOMERIC FLUOROPOLYMERS CONTAINING A CROSSLINKABLE CYANO GROUP NIPPON MEKTRON, LIMITED (JP) 1997-09-30 US disclosed
CN-1132200-A Bisaminothiophenol compound, process for producing the same and curing agent for fluorine-containing elastomer comprising the same NIPPON MEKTRON KK (JP) 1996-10-02 CN disclosed
JP-H08143535-A BISAMINOTHIOPHENOL COMPOUND, ITS PRODUCTION AND CURING AGENT FOR ELASTOMER CONTAINING FLUORINE COMPRISING THE SAME NIPPON MEKTRON LTD 1996-06-04 JP disclosed
EP-0712842-A1 Bisaminothiophenol compound, process for producing the same and curing agent for fluorine-containing elastomer comprising the same NIPPON MEKTRON, LTD. (JP) 1996-05-22 EP disclosed
EP-0712842-A1 Bisaminothiophenol compound, process for producing the same and curing agent for fluorine-containing elastomer comprising the same NIPPON MEKTRON, LTD. (JP) 1996-05-22 EP disclosed