Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL437541 | 0.83 | HRH4 (0.38) | LMNAHRH4HRH3CYP2C9TSHR | |
| Histamine SCHEMBL11002055 | 0.82 | TDP1 (0.40) | LMNAHRH4HRH3CYP2C9TSHR | |
| Histamine SCHEMBL9863744 | 0.82 | TDP1 (0.40) | LMNAHRH4HRH3CYP2C9TSHR | |
| SCHEMBL10853745 | 0.82 | LMNA (0.41) | LMNA | |
| Histamine SCHEMBL10947437 | 0.81 | HRH4 (0.41) | LMNAHRH4HRH3CYP2C9TSHR | |
| Histamine SCHEMBL9753206 | 0.81 | HRH4 (0.44) | LMNAHRH4HRH3CYP2C9TSHR | |
| Histamine SCHEMBL289072 | 0.81 | HRH4 (0.42) | LMNAHRH4HRH3CYP2C9TSHR | |
| Histamine SCHEMBL5447892 | 0.81 | — | — | |
| Histamine SCHEMBL7444650 | 0.81 | HRH4 (0.42) | LMNAHRH4HRH3CYP2C9TSHR | |
| Histamine SCHEMBL1668636 | 0.81 | HRH4 (0.42) | LMNAHRH4HRH3CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1201820-C | Compositions containing benzimidazolones and progestogens | WYETH CORP (US) | 2005-05-18 | — | — | CN | disclosed |
| CN-1152020-C | Benzimidazolrone and analogues, and the use as ligand of progesterone | �Ʒ� | 2004-06-02 | — | — | CN | disclosed |
| EP-0996037-B1 | Polyvinyl acetals having imido groups and use thereof in photosensitive compositions | KODAK POLYCHROME GRAPHICS GMBH (DE) | 2003-01-15 | — | — | EP | disclosed |
| CN-1349411-A | Compositions containing benzimidazolones and progestogens | AMERICAN HOME PROD (US) | 2002-05-15 | — | — | CN | disclosed |
| CN-1349511-A | Benzimidazolrone and analogues, and the use as ligand of progesterone | AMERICAN HOME PROD (US) | 2002-05-15 | — | — | CN | disclosed |
| US-6087066-A | Polyvinyl acetals having imido groups and use thereof in photosensitive compositions | KODAK POLYCHROME GRAPHICS LLC (US) | 2000-07-11 | — | — | US | disclosed |
| EP-0996037-A2 | Polyvinyl acetals having imido groups and use thereof in photosensitive compositions | Kodak Polychrome Graphics GmbH (DE) | 2000-04-26 | — | — | EP | disclosed |