Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TNF | P01375 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29174154 | 0.90 | TNF (0.60) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL29883153 | 0.90 | TNF (0.60) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL4825769 | 0.90 | PDE4D (0.64) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL7172764 | 0.88 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL4823187 | 0.85 | LMNA (0.55) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL4822401 | 0.85 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL9115691 | 0.84 | TNF (0.58) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL27684145 | 0.83 | LMNA (0.54) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL2989854 | 0.82 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL21494493 | 0.82 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0918746-B1 | IMMUNOTHERAPEUTIC AGENTS AND THEIR USE IN THE REDUCTION OF CYTOKINE LEVELS | CELGENE CORP (US) | 2003-04-09 | — | — | EP | claimed |