Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 6/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7176932 | 1.00 | PGR (0.42) | PGRPOLBMAPTARDAO | |
| SCHEMBL20079378 | 0.85 | POLB (0.55) | PGRPOLBMAPTTNKSNOS3 | |
| SCHEMBL7178509 | 0.83 | PGR (0.38) | PGRPOLBMAPTDAOTNKS | |
| SCHEMBL7187351 | 0.83 | PGR (0.38) | PGRPOLBMAPTDAOTNKS | |
| SCHEMBL7185230 | 0.76 | ALDH1A1 (0.54) | PGRPOLBMAPTAR | |
| SCHEMBL7513143 | 0.76 | POLB (0.68) | PGRPOLBMAPTDAO | |
| SCHEMBL7183033 | 0.75 | MAPT (0.43) | PGRMAPTDAOTNKSNOS3 | |
| SCHEMBL7191700 | 0.74 | PGR (0.44) | PGRPOLBMAPTHRH3TNKS | |
| SCHEMBL7187323 | 0.74 | PGR (0.44) | PGRPOLBMAPTHRH3TNKS | |
| SCHEMBL3932874 | 0.74 | MAPT (0.61) | PGRMAPTDAOTNKSNOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |