Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 6/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7191700 | 1.00 | PGR (0.44) | PGRALKPDE4BMAPTTNKS | |
| SCHEMBL7178509 | 0.87 | PGR (0.38) | PGRALKPDE4BMAPTTNKS | |
| SCHEMBL7187351 | 0.87 | PGR (0.38) | PGRALKPDE4BMAPTTNKS | |
| SCHEMBL20079378 | 0.74 | POLB (0.55) | PGRALKMAPTTNKSPOLB | |
| SCHEMBL7184073 | 0.74 | PGR (0.42) | PGRALKMAPTTNKSPOLB | |
| SCHEMBL7176932 | 0.74 | PGR (0.42) | PGRALKMAPTTNKSPOLB | |
| SCHEMBL7185221 | 0.73 | POLB (0.44) | PGRMAPTPOLB | |
| SCHEMBL7191331 | 0.73 | MAPT (0.35) | ALKMAPTTNKSTNKS2PARP1 | |
| SCHEMBL7183914 | 0.70 | HSD11B1 (0.37) | MAPTTNKSPOLBTNKS2 | |
| SCHEMBL7187300 | 0.70 | PDE4B (0.48) | PGRPDE4BTNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| EP-1196391-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005770-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-25 | — | — | WO | disclosed |