Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | PDE9A | O76083 | 2/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452685 | 0.90 | B3GNT2 (0.45) | ALDH1A1HSP90AA1MAPTMEN1CYP1A2 | |
| SCHEMBL7178381 | 0.85 | ALDH1A1 (0.69) | ALDH1A1HSP90AA1MAPTMEN1CYP1A2 | |
| SCHEMBL7186419 | 0.83 | ALDH1A1 (0.48) | ALDH1A1HSP90AA1MAPTMEN1CYP1A2 | |
| SCHEMBL7184073 | 0.76 | PGR (0.42) | MAPTPOLBPGRAR | |
| SCHEMBL7178557 | 0.76 | MEN1 (0.56) | ALDH1A1HSP90AA1MAPTMEN1CYP1A2 | |
| SCHEMBL7513143 | 0.76 | POLB (0.68) | ALDH1A1HSP90AA1MAPTMEN1CYP1A2 | |
| SCHEMBL13195012 | 0.74 | MAPT (0.57) | ALDH1A1HSP90AA1MAPTMEN1CYP1A2 | |
| SCHEMBL30167009 | 0.74 | MAPT (0.57) | ALDH1A1HSP90AA1MAPTMEN1CYP1A2 | |
| SCHEMBL7456189 | 0.73 | B3GNT2 (0.43) | ALDH1A1HSP90AA1MAPTMEN1CYP1A2 | |
| SCHEMBL7351991 | 0.73 | ALDH1A1 (0.48) | ALDH1A1HSP90AA1MAPTMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |