Sugi Predict

Sugi Predict / Compounds / SCHEMBL7184121

SCHEMBL7184121

SCHEMBL7184121

Cc1cccc(C)c1C(=O)[PH](=O)c1c(Cl)cc(C(=O)c2ccccc2)c(Cl)c1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ LMNA P02545 2/20 0.36
▸ GAA P10253 1/20 0.36
▸ POLB P06746 1/20 0.35
▸ MAPK14 Q16539 2/20 0.35
▸ BCL2L1 Q07817 1/20 0.34
▸ MYC P01106 1/20 0.34
▸ PTGS2 P35354 1/20 0.34
▸ RORC P51449 3/20 0.34
▸ TP53 P04637 1/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ ATM Q13315 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ C5AR1 P21730 1/20 0.34
▸ NPSR1 Q6W5P4 2/20 0.33
▸ MAPK13 O15264 1/20 0.33
▸ MAPK12 P53778 1/20 0.33
▸ MAPK11 Q15759 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7187502 0.95 RORC (0.38) MAPTALDH1A1LMNAGAAPOLB
SCHEMBL7184532 0.92 TP53 (0.38) MAPTALDH1A1LMNAPOLBBCL2L1
SCHEMBL7174653 0.90 LMNA (0.38) MAPTALDH1A1LMNAGAAPOLB
SCHEMBL7189826 0.89 ALDH1A1 (0.37) MAPTALDH1A1LMNAGAACYP2C9
SCHEMBL7182322 0.89 TP53 (0.34) MAPTALDH1A1LMNAGAABCL2L1
SCHEMBL7183278 0.88 MAPT (0.38) MAPTALDH1A1LMNAMAPK14CYP2C9
SCHEMBL7177494 0.87 TP53 (0.35) MAPTALDH1A1LMNAGAAPOLB
SCHEMBL7174816 0.86 MAPT (0.37) MAPTALDH1A1LMNAGAAMAPK14
SCHEMBL7174760 0.85 LMNA (0.39) MAPTALDH1A1LMNAGAAMAPK14
SCHEMBL7174634 0.85 MAPT (0.42) MAPTALDH1A1LMNAGAATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 MAPT 4870/4885ALDH1A1 3416/4885LMNA 3241/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 MAPT 4859/4885ALDH1A1 3984/4885LMNA 3247/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.