Sugi Predict

Sugi Predict / Compounds / SCHEMBL7189826

SCHEMBL7189826

SCHEMBL7189826

O=C(c1ccccc1)c1cc(Cl)c([PH](=O)C(=O)c2c(Cl)cccc2Cl)c(Cl)c1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.37
▸ LMNA P02545 2/20 0.37
▸ MAPT P10636 2/20 0.37
▸ L3MBTL1 Q9Y468 2/20 0.37
▸ ATM Q13315 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.37
▸ GAA P10253 2/20 0.36
▸ AKR1C3 P42330 1/20 0.35
▸ KCNK3 O14649 1/20 0.35
▸ KCNK9 Q9NPC2 1/20 0.35
▸ ALOX15 P16050 2/20 0.34
▸ CYP2C9 P11712 2/20 0.34
▸ TSHR P16473 1/20 0.34
▸ NR4A1 P22736 1/20 0.34
▸ CYP2C8 P10632 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ USP2 O75604 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ KEAP1 Q14145 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7187502 0.92 RORC (0.38) ALDH1A1LMNAMAPTGAACYP2C9
SCHEMBL7183639 0.89 L3MBTL1 (0.39) ALDH1A1LMNAMAPTL3MBTL1ATM
SCHEMBL7184121 0.89 MAPT (0.36) ALDH1A1LMNAMAPTL3MBTL1ATM
SCHEMBL7180744 0.89 MAPT (0.41) ALDH1A1LMNAMAPTGAAKCNK3
SCHEMBL7174634 0.86 MAPT (0.42) ALDH1A1LMNAMAPTGAAALOX15
SCHEMBL7187673 0.86 KMT2A (0.40) ALDH1A1LMNAMAPTL3MBTL1GAA
SCHEMBL7186454 0.86 NR1H2 (0.38) LMNAMAPTKCNK3KCNK9CYP2C9
SCHEMBL7184532 0.85 TP53 (0.38) ALDH1A1LMNAMAPTAKR1C3MEN1
SCHEMBL7180948 0.85 ALDH1A1 (0.40) ALDH1A1LMNAMAPTL3MBTL1ATM
SCHEMBL7177494 0.83 TP53 (0.35) ALDH1A1LMNAMAPTGAAALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ALDH1A1 3416/4885LMNA 3241/4885MAPT 4870/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ALDH1A1 3984/4885LMNA 3247/4885MAPT 4859/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.