Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7180271 | 0.83 | L3MBTL1 (0.43) | MAPTMEN1KMT2ACYP3A4SMN1; SMN2 | |
| SCHEMBL22468511 | 0.82 | ALDH1A1 (0.36) | MAPTMEN1KMT2ACYP3A4SMN1; SMN2 | |
| SCHEMBL117981 | 0.79 | FGFR4 (0.51) | MAPTMEN1KMT2ACYP3A4SMN1; SMN2 | |
| SCHEMBL31315323 | 0.79 | FGFR4 (0.51) | MAPTMEN1KMT2ACYP3A4SMN1; SMN2 | |
| SCHEMBL9952081 | 0.79 | MAPT (0.54) | MAPTMEN1KMT2ACYP3A4SMN1; SMN2 | |
| SCHEMBL7190772 | 0.79 | ALDH1A1 (0.44) | MAPTMEN1KMT2ACYP3A4SMN1; SMN2 | |
| SCHEMBL7449702 | 0.77 | MAPT (0.50) | MAPTMEN1KMT2ACYP3A4SMN1; SMN2 | |
| SCHEMBL27162934 | 0.76 | FGFR4 (0.51) | MAPTMEN1KMT2ACYP3A4SMN1; SMN2 | |
| SCHEMBL7188544 | 0.76 | MAPK1 (0.55) | MAPTMEN1KMT2ACYP3A4SMN1; SMN2 | |
| SCHEMBL29431640 | 0.76 | MAPT (0.54) | MAPTMEN1KMT2ACYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| CN-1374952-A | Benzimidazolone derivatives and their use as phosphodiesterase inhibibors | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-10-16 | — | — | CN | disclosed |
| EP-1196391-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005770-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-25 | — | — | WO | disclosed |