SCHEMBL7184512

SCHEMBL7184512

Nc1cc(Cl)cc(C(=O)c2ccc(N)cc2Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 1/20 0.45
JAK2 O60674 1/20 0.43
TYK2 P29597 1/20 0.43
HTT P42858 1/20 0.42
MAPT P10636 2/20 0.42
HSD17B10 Q99714 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
RAB9A P51151 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
NR1H4 Q96RI1 1/20 0.40
MAPK13 O15264 1/20 0.40
MAPK12 P53778 1/20 0.40
MAPK11 Q15759 1/20 0.40
MAPK14 Q16539 1/20 0.40
CHRM2 P08172 1/20 0.40
CHRM3 P20309 1/20 0.40
MAOA P21397 1/20 0.40
HTR2C P28335 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1149168 0.83 SRD5A2 (0.60) SRD5A2JAK2TYK2HTTMAPT
SCHEMBL7183309 0.82 SRD5A2 (0.54) SRD5A2JAK2TYK2HTTMAPT
SCHEMBL11710988 0.82 ALOX15 (0.52) SRD5A2HTTMAPTHSD17B10SMN1; SMN2
SCHEMBL7090488 0.82 JAK2 (0.53) SRD5A2JAK2TYK2MAPTHSD17B10
SCHEMBL7194395 0.81 HSD17B10 (0.58) SRD5A2JAK2TYK2MAPTHSD17B10
SCHEMBL7189753 0.80 CYP3A4 (0.55) SRD5A2CYP3A4ALDH1A1THRBTP53
SCHEMBL5963546 0.79 MAPK13 (0.58) SRD5A2JAK2TYK2MAPTHSD17B10
SCHEMBL7194361 0.79 CNR1 (0.46) SRD5A2HTTSMN1; SMN2CA1CA2
Chlorobenzene SCHEMBL27529703 0.79 MAPK14 (0.55) SRD5A2MAPTHSD17B10SMN1; SMN2RAB9A
SCHEMBL8309451 0.77 JAK2 (0.61) SRD5A2JAK2TYK2HTTMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030064235-A1 Optical members made of polymide resins MITSUI CHEMICALS, INC. (JP) 2003-04-03 US disclosed
EP-1237015-A1 OPTICAL MEMBERS MADE OF POLYIMIDE RESINS Mitsui Chemicals, Inc. (JP) 2002-09-04 EP disclosed