Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.61 |
| ▸ | TYK2 | P29597 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7183309 | 0.86 | SRD5A2 (0.54) | JAK2TYK2SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL5963546 | 0.83 | MAPK13 (0.58) | JAK2TYK2SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL1149168 | 0.83 | SRD5A2 (0.60) | JAK2TYK2SMN1; SMN2MAPTKDM4E | |
| SCHEMBL7090488 | 0.82 | JAK2 (0.53) | JAK2TYK2SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL8309926 | 0.81 | RAB9A (0.50) | JAK2TYK2SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3531609 | 0.80 | SRD5A2 (0.49) | JAK2TYK2MAPTALDH1A1RAB9A | |
| SCHEMBL29088628 | 0.80 | MAPT (0.51) | JAK2TYK2SMN1; SMN2MAPTALDH1A1 | |
| Chlorobenzene SCHEMBL27529703 | 0.79 | MAPK14 (0.55) | SMN1; SMN2MAPTALDH1A1KDM4ERAB9A | |
| SCHEMBL7194395 | 0.78 | HSD17B10 (0.58) | JAK2TYK2SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7184512 | 0.77 | SRD5A2 (0.45) | JAK2TYK2SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |