Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.56 |
| ▸ | WNK1 | Q9H4A3 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | ALDH3A1 | P30838 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7184647 | 1.00 | HCAR3 (0.56) | HCAR3WNK1MEN1KMT2AALDH1A1 | |
| SCHEMBL19203959 | 0.87 | WNK1 (0.70) | HCAR3WNK1MEN1KMT2AALDH1A1 | |
| SCHEMBL7179470 | 0.83 | HCAR3 (0.53) | HCAR3WNK1MEN1KMT2AALDH1A1 | |
| SCHEMBL7179468 | 0.83 | HCAR3 (0.53) | HCAR3WNK1MEN1KMT2AALDH1A1 | |
| SCHEMBL7180257 | 0.83 | HCAR3 (0.60) | HCAR3WNK1MEN1KMT2AALDH1A1 | |
| SCHEMBL7180261 | 0.83 | HCAR3 (0.60) | HCAR3WNK1MEN1KMT2AALDH1A1 | |
| SCHEMBL20337694 | 0.82 | MAPT (0.56) | HCAR3WNK1MEN1KMT2AALDH1A1 | |
| SCHEMBL4440176 | 0.82 | HCAR3 (0.54) | HCAR3WNK1MEN1KMT2AALDH1A1 | |
| SCHEMBL4440170 | 0.82 | HCAR3 (0.54) | HCAR3WNK1MEN1KMT2AALDH1A1 | |
| SCHEMBL21294007 | 0.80 | HCAR3 (0.60) | HCAR3WNK1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| EP-1196391-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005770-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-25 | — | — | WO | disclosed |