Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.39 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.39 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7189512 | 0.86 | ESR1 (0.42) | ESR1ESR2ALDH1A1MAPTTUBB4A | |
| SCHEMBL1359561 | 0.86 | ESR1 (0.47) | ESR1ESR2ALDH1A1MAPTTUBB4A | |
| SCHEMBL7182672 | 0.86 | ALDH1A1 (0.46) | ESR1ESR2ALDH1A1MAPTRAB9A | |
| SCHEMBL7194280 | 0.86 | CYP1B1 (0.42) | ESR1ESR2ALDH1A1MAPTCYP1A1 | |
| SCHEMBL6050365 | 0.85 | CYP1A2 (0.43) | ESR1ESR2ALDH1A1MAPTCYP1A1 | |
| SCHEMBL7189157 | 0.83 | ESR1 (0.44) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL7189159 | 0.83 | ESR1 (0.44) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL7181164 | 0.80 | ESR1 (0.43) | ESR1ESR2ALDH1A1MAPTTUBB4A | |
| SCHEMBL8499724 | 0.79 | ESR1 (0.45) | ESR1ESR2ALDH1A1TUBB4ATUBB | |
| SCHEMBL7190056 | 0.79 | HSD17B10 (0.41) | ALDH1A1MAPTCYP1A1CYP1B1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | disclosed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0835867-A1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |