Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.42 |
| ▸ | DRD1 | P21728 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7182672 | 0.89 | ALDH1A1 (0.46) | ESR1ESR2DRD1ALDH1A1DRD2 | |
| SCHEMBL7190056 | 0.87 | HSD17B10 (0.41) | DRD1ALDH1A1DRD2DRD4DRD5 | |
| SCHEMBL7187373 | 0.87 | ALDH1A1 (0.49) | ESR1ESR2ALDH1A1RAB9AMAPT | |
| SCHEMBL7187142 | 0.86 | ESR1 (0.46) | ESR1ESR2DRD1ALDH1A1RAB9A | |
| SCHEMBL7191254 | 0.83 | ESR1 (0.44) | ESR1ESR2ALDH1A1L3MBTL1MAPT | |
| SCHEMBL1360086 | 0.81 | MAOB (0.46) | ESR1ESR2RAB9A | |
| SCHEMBL7194280 | 0.79 | CYP1B1 (0.42) | ESR1ESR2ALDH1A1RAB9AMAPT | |
| SCHEMBL6050365 | 0.78 | CYP1A2 (0.43) | ESR1ESR2ALDH1A1MAPTCYP1B1 | |
| SCHEMBL8500438 | 0.77 | MAPT (0.44) | ESR1ESR2ALDH1A1L3MBTL1SCN9A | |
| SCHEMBL25908289 | 0.76 | DRD1 (0.59) | DRD1ALDH1A1L3MBTL1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | disclosed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0835867-A1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |