Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7189512 | 0.89 | ESR1 (0.42) | ALDH1A1MAPTRAB9AESR1ESR2 | |
| SCHEMBL7190056 | 0.89 | HSD17B10 (0.41) | ALDH1A1MAPTRAB9AKDM4ELMNA | |
| SCHEMBL7187373 | 0.89 | ALDH1A1 (0.49) | ALDH1A1MAPTRAB9AESR1ESR2 | |
| SCHEMBL7187142 | 0.86 | ESR1 (0.46) | ALDH1A1MAPTRAB9AESR1ESR2 | |
| SCHEMBL7194280 | 0.86 | CYP1B1 (0.42) | ALDH1A1MAPTRAB9AESR1ESR2 | |
| SCHEMBL6050365 | 0.85 | CYP1A2 (0.43) | ALDH1A1MAPTESR1ESR2CYP2A6 | |
| SCHEMBL7183993 | 0.83 | ESR1 (0.59) | ESR1ESR2 | |
| SCHEMBL7183989 | 0.83 | ESR1 (0.59) | ESR1ESR2 | |
| SCHEMBL668420 | 0.79 | ALDH1A1 (0.44) | ALDH1A1MAPTRAB9AKDM4ELMNA | |
| SCHEMBL7538596 | 0.79 | WDR5 (0.47) | ALDH1A1MAPTRAB9AESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | disclosed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0835867-A1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |