Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7182672 | 0.89 | ALDH1A1 (0.46) | RAB9AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL7187373 | 0.87 | ALDH1A1 (0.49) | RAB9AALDH1A1MAPTALOX5CYP1A1 | |
| SCHEMBL7189512 | 0.87 | ESR1 (0.42) | RAB9AALDH1A1MAPTCYP1B1KDM4E | |
| SCHEMBL7194280 | 0.86 | CYP1B1 (0.42) | NPSR1RAB9AALDH1A1MAPTCYP1A1 | |
| SCHEMBL7190627 | 0.83 | ESR1 (0.52) | CYP1A1CYP1B1 | |
| SCHEMBL7190635 | 0.83 | ESR1 (0.52) | CYP1A1CYP1B1 | |
| SCHEMBL7182654 | 0.83 | ALOX5 (0.43) | HSD17B10NPSR1ALDH1A1MAPTALOX5 | |
| SCHEMBL7187142 | 0.79 | ESR1 (0.46) | RAB9AALDH1A1MAPTCYP1A1CYP1B1 | |
| SCHEMBL6050365 | 0.78 | CYP1A2 (0.43) | ALDH1A1MAPTALOX5CYP1A1CYP1B1 | |
| SCHEMBL8500470 | 0.77 | PTGDR2 (0.39) | RAB9AMMP3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | disclosed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0835867-A1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |