Sugi Predict

Sugi Predict / Compounds / SCHEMBL7187692

SCHEMBL7187692

SCHEMBL7187692

Cc1cc(OC(C)C)ccc1PC(=O)c1c(Cl)cccc1Cl.[LiH]

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.38
▸ GAA P10253 3/20 0.38
▸ KDM4E B2RXH2 2/20 0.38
▸ HPGD P15428 2/20 0.38
▸ LMNA P02545 2/20 0.38
▸ TDP1 Q9NUW8 1/20 0.36
▸ POLB P06746 1/20 0.36
▸ KMT2A Q03164 4/20 0.36
▸ MEN1 O00255 3/20 0.36
▸ PKM P14618 1/20 0.36
▸ RXRA P19793 1/20 0.35
▸ RXRB P28702 1/20 0.35
▸ CNR1 P21554 1/20 0.35
▸ PARP10 Q53GL7 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ MAPT P10636 2/20 0.34
▸ ALOX12 P18054 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ TP53 P04637 1/20 0.34
▸ MCL1 Q07820 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7177496 0.96 TYK2 (0.37) ALDH1A1GAAKDM4EHPGDLMNA
SCHEMBL7182853 0.93 PNLIP (0.36) ALDH1A1GAAHPGDLMNAMAPT
SCHEMBL7186834 0.89 ALDH1A1 (0.39) ALDH1A1GAAKDM4EHPGDLMNA
SCHEMBL7180691 0.88 SMN1; SMN2 (0.36) ALDH1A1TDP1KMT2AMEN1PKM
Lithium SCHEMBL7186703 0.87 TDP1 (0.35) ALDH1A1LMNATDP1KMT2AMEN1
SCHEMBL7190032 0.87 RORC (0.37) ALDH1A1GAAKDM4EHPGDLMNA
SCHEMBL7189441 0.87 TYK2 (0.36) ALDH1A1GAAKDM4EHPGDLMNA
SCHEMBL7189833 0.86 MAPT (0.41) ALDH1A1GAAKDM4EKMT2AMEN1
SCHEMBL7176019 0.85 KMT2A (0.41) ALDH1A1GAAKDM4EHPGDKMT2A
SCHEMBL7183348 0.85 CA12 (0.39) ALDH1A1GAAHPGDLMNATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ALDH1A1 3416/4885GAA 4753/4885KDM4E 3226/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ALDH1A1 3984/4885GAA 4793/4885KDM4E 2651/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.