Sugi Predict

Sugi Predict / Compounds / SCHEMBL7189441

SCHEMBL7189441

SCHEMBL7189441

Cc1cccc(Cl)c1C(=O)Pc1ccc(OC(C)C)cc1OC(C)C.[LiH]

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TYK2 P29597 1/20 0.36
▸ ALDH1A1 P00352 2/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ RORC P51449 3/20 0.34
▸ ITGB1 P05556 4/20 0.34
▸ ITGA4 P13612 4/20 0.34
▸ ITGA2 P17301 1/20 0.34
▸ ITGB7 P26010 1/20 0.34
▸ ELANE P08246 1/20 0.34
▸ ABL1 P00519 1/20 0.34
▸ SRC P12931 1/20 0.34
▸ TRPM4 Q8TD43 1/20 0.33
▸ IRAK4 Q9NWZ3 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ CNR1 P21554 1/20 0.32
▸ RXRA P19793 1/20 0.32
▸ RXRB P28702 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lithium SCHEMBL7189444 0.98 TYK2 (0.36) TYK2ALDH1A1KDM4ELMNAGAA
SCHEMBL7190032 0.94 RORC (0.37) ALDH1A1KDM4ELMNAGAAHPGD
SCHEMBL7177670 0.92 ALDH1A1 (0.37) ALDH1A1KDM4EGAAHPGDIRAK4
Lithium SCHEMBL7190038 0.92 RORC (0.37) ALDH1A1KDM4ELMNAGAAHPGD
SCHEMBL7177496 0.91 TYK2 (0.37) TYK2ALDH1A1KDM4ELMNAGAA
Lithium SCHEMBL7177679 0.89 ALDH1A1 (0.37) ALDH1A1KDM4EGAAHPGDIRAK4
SCHEMBL7179731 0.89 ABL1 (0.33) TYK2ITGB1ITGA4ITGA2ITGB7
SCHEMBL7183497 0.88 BRPF1 (0.39) ALDH1A1LMNAHPGDELANEKMT2A
SCHEMBL7190066 0.87 TYK2 (0.36) TYK2ALDH1A1KDM4ELMNAGAA
SCHEMBL7181314 0.87 DHODH (0.34) TYK2ITGB1ITGA4ITGA2ITGB7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 TYK2 1285/4885ALDH1A1 3416/4885KDM4E 3226/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 TYK2 1333/4885ALDH1A1 3984/4885KDM4E 2651/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.