Sugi Predict

Sugi Predict / Compounds / SCHEMBL7187697

SCHEMBL7187697

SCHEMBL7187697

Cc1cccc(Cl)c1C(=O)Pc1ccc(-c2ccccc2)cc1.[LiH]

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FABP3 P05413 2/20 0.48
▸ FABP4 P15090 2/20 0.48
▸ DHODH Q02127 2/20 0.41
▸ ALDH2 P05091 1/20 0.40
▸ MEN1 O00255 2/20 0.39
▸ LMNA P02545 2/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ TYK2 P29597 1/20 0.39
▸ ITGB1 P05556 8/20 0.39
▸ ITGA4 P13612 8/20 0.39
▸ ITGB7 P26010 6/20 0.39
▸ ITGA2 P17301 1/20 0.39
▸ TRPM4 Q8TD43 1/20 0.38
▸ PTGS2 P35354 1/20 0.38
▸ NPC1 O15118 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ HPGD P15428 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ ITGB2 P05107 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7175177 0.91 FABP3 (0.46) FABP3FABP4LMNAKMT2ATYK2
SCHEMBL7182551 0.91 LMNA (0.45) FABP3FABP4DHODHMEN1LMNA
SCHEMBL7183770 0.90 FABP3 (0.40) FABP3FABP4LMNAPTGS2MAPT
SCHEMBL7175322 0.87 TYK2 (0.41) FABP3FABP4ALDH2KMT2ATYK2
SCHEMBL7185568 0.85 FABP3 (0.40) FABP3FABP4MEN1LMNAKMT2A
SCHEMBL7177520 0.83 FABP4 (0.49) FABP4DHODHMEN1LMNAKMT2A
SCHEMBL7182030 0.82 KMT2A (0.41) LMNAKMT2ATYK2PTGS2NPC1
SCHEMBL7179685 0.81 ALDH1A1 (0.48) FABP3FABP4MEN1KMT2ATYK2
SCHEMBL7179761 0.81 FABP3 (0.46) FABP3FABP4DHODHMEN1LMNA
SCHEMBL7179694 0.80 FFAR1 (0.45) LMNAPTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 FABP3 3252/4885FABP4 4550/4885DHODH 2946/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 FABP3 2807/4885FABP4 4256/4885DHODH 2970/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.