Sugi Predict

Sugi Predict / Compounds / SCHEMBL7188332

SCHEMBL7188332

SCHEMBL7188332

COc1cccc(Cl)c1C(=O)[PH](=O)c1c(OC)c(Cl)c(C(=O)c2ccccc2)c(Cl)c1OC

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TUBB4A P04350 4/20 0.40
▸ TUBB P07437 4/20 0.40
▸ TUBA3C P0DPH7 4/20 0.40
▸ TUBA1B P68363 4/20 0.40
▸ TUBA4A P68366 4/20 0.40
▸ TUBB4B P68371 4/20 0.40
▸ TUBB3 Q13509 4/20 0.40
▸ TUBB2A Q13885 4/20 0.40
▸ TUBB8 Q3ZCM7 4/20 0.40
▸ TUBA3E Q6PEY2 4/20 0.40
▸ TUBA1A Q71U36 4/20 0.40
▸ TUBA1C Q9BQE3 4/20 0.40
▸ TUBB6 Q9BUF5 4/20 0.40
▸ TUBB2B Q9BVA1 4/20 0.40
▸ TUBB1 Q9H4B7 4/20 0.40
▸ MAPT P10636 4/20 0.39
▸ RAB9A P51151 2/20 0.39
▸ ATM Q13315 2/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ LMNA P02545 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7182465 0.94 CA12 (0.42) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL7187002 0.93 ALDH1A1 (0.40) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL7180790 0.91 CA12 (0.41) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL7174982 0.90 TUBB4A (0.40) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL7189330 0.88 ALDH1A1 (0.38) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL7181182 0.88 TUBB4A (0.39) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL7188965 0.86 TUBB4A (0.41) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL7190116 0.85 RAB9A (0.41) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL7189231 0.85 RAB9A (0.40) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL7182523 0.84 MAPT (0.42) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 TUBB4A 4123/4885TUBB 3780/4885TUBA3C 2136/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 TUBB4A 4305/4885TUBB 4090/4885TUBA3C 2222/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.