Sugi Predict

Sugi Predict / Compounds / SCHEMBL7189330

SCHEMBL7189330

SCHEMBL7189330

COc1c(Cl)c(C(=O)c2ccccc2)c(Cl)c(OC)c1[PH](=O)C(=O)c1c(C)cccc1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.38
▸ MAPT P10636 2/20 0.38
▸ LMNA P02545 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ TAS1R3 Q7RTX0 1/20 0.37
▸ TAS1R1 Q7RTX1 1/20 0.37
▸ TAS1R2 Q8TE23 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ TUBB4A P04350 4/20 0.36
▸ TUBB P07437 4/20 0.36
▸ TUBA3C P0DPH7 4/20 0.36
▸ TUBA1B P68363 4/20 0.36
▸ TUBA4A P68366 4/20 0.36
▸ TUBB4B P68371 4/20 0.36
▸ TUBB3 Q13509 4/20 0.36
▸ TUBB2A Q13885 4/20 0.36
▸ TUBB8 Q3ZCM7 4/20 0.36
▸ TUBA3E Q6PEY2 4/20 0.36
▸ TUBA1A Q71U36 4/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7182760 0.94 TAS1R3 (0.36) ALDH1A1MAPTLMNAGAATAS1R3
SCHEMBL7187002 0.93 ALDH1A1 (0.40) ALDH1A1MAPTLMNAGAATAS1R3
SCHEMBL7175806 0.91 ALDH1A1 (0.38) ALDH1A1MAPTLMNAGAATAS1R3
SCHEMBL7188332 0.88 TUBB4A (0.40) ALDH1A1MAPTLMNAKDM4EHSD17B10
SCHEMBL7186758 0.88 KMT2A (0.38) ALDH1A1MAPTLMNAGAATAS1R3
SCHEMBL7180497 0.87 ALDH1A1 (0.41) ALDH1A1MAPTLMNAGAARORC
SCHEMBL7189208 0.85 TAS1R3 (0.35) ALDH1A1MAPTLMNATAS1R3TAS1R1
SCHEMBL7189353 0.84 TUBB4A (0.40) ALDH1A1MAPTLMNAGAATAS1R3
SCHEMBL7180913 0.84 ALDH1A1 (0.40) ALDH1A1MAPTLMNAGAATAS1R3
SCHEMBL7182465 0.84 CA12 (0.42) ALDH1A1MAPTLMNAGAAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ALDH1A1 3416/4885MAPT 4870/4885LMNA 3241/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ALDH1A1 3984/4885MAPT 4859/4885LMNA 3247/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.