Sugi Predict

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SCHEMBL7189208

SCHEMBL7189208

COc1c(Cl)c(C(=O)c2ccccc2)c(Cl)c(OC)c1[PH](=O)C(=O)c1c(C)cc(C)cc1C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TAS1R3 Q7RTX0 3/20 0.35
▸ TAS1R1 Q7RTX1 3/20 0.35
▸ TAS1R2 Q8TE23 3/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ ATM Q13315 1/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ CNR2 P34972 1/20 0.34
▸ TUBB4A P04350 1/20 0.34
▸ TUBB P07437 1/20 0.34
▸ TUBA3C P0DPH7 1/20 0.34
▸ TUBA1B P68363 1/20 0.34
▸ TUBA4A P68366 1/20 0.34
▸ TUBB4B P68371 1/20 0.34
▸ TUBB3 Q13509 1/20 0.34
▸ TUBB2A Q13885 1/20 0.34
▸ TUBB8 Q3ZCM7 1/20 0.34
▸ TUBA3E Q6PEY2 1/20 0.34
▸ TUBA1A Q71U36 1/20 0.34
▸ TUBA1C Q9BQE3 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7182760 0.90 TAS1R3 (0.36) TAS1R3TAS1R1TAS1R2MEN1KMT2A
SCHEMBL7181244 0.90 TNFRSF1A (0.35) TAS1R3TAS1R1TAS1R2ATMCNR2
SCHEMBL7177974 0.88 TAS1R3 (0.34) TAS1R3TAS1R1TAS1R2ATMCNR2
SCHEMBL7182193 0.88 HPGD (0.37) MEN1KMT2AATMCNR2HPGD
SCHEMBL7189545 0.88 KMT2A (0.36) TAS1R3TAS1R1TAS1R2MEN1KMT2A
SCHEMBL7174833 0.86 KMT2A (0.39) MEN1KMT2AATMRAB9AHPGD
SCHEMBL7189330 0.85 ALDH1A1 (0.38) TAS1R3TAS1R1TAS1R2MEN1KMT2A
SCHEMBL7187002 0.84 ALDH1A1 (0.40) TAS1R3TAS1R1TAS1R2MEN1KMT2A
SCHEMBL7182465 0.83 CA12 (0.42) MEN1KMT2AATMRAB9ACNR2
SCHEMBL7180822 0.82 ATM (0.39) MEN1KMT2AATMRAB9ACNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 TAS1R3 2990/4885TAS1R1 3374/4885TAS1R2 3865/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 TAS1R3 3176/4885TAS1R1 3927/4885TAS1R2 4103/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.