SCHEMBL7189375

SCHEMBL7189375

C[SiH](C)Oc1cc(C(C)(C)C)ccc1/C=C/c1ccc(C(C)(C)C)cc1

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 5/20 0.40
CYP1A1 P04798 5/20 0.40
CYP1B1 Q16678 5/20 0.40
NFE2L2 Q16236 2/20 0.40
APP P05067 4/20 0.39
MAPT P10636 1/20 0.39
NR1H2 P55055 1/20 0.38
NR1H3 Q13133 1/20 0.38
CYP19A1 P11511 1/20 0.36
TRPV1 Q8NER1 6/20 0.35
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7189386 1.00 CYP1A2 (0.40) CYP1A2CYP1A1CYP1B1NFE2L2APP
SCHEMBL8648687 0.92 TUBB4A (0.39) CYP1A2CYP1A1CYP1B1NFE2L2APP
SCHEMBL411850 0.80 CA1 (0.36) MAPTCA1CA2CA9
SCHEMBL5204561 0.80 CA1 (0.39) MAPTCA1CA2CA9
SCHEMBL7366742 0.79 SCN10A (0.33) MAPTCA1CA2CA9
SCHEMBL12098518 0.78 RXRA (0.46) CYP1A2CYP1A1CYP1B1MAPT
SCHEMBL4261454 0.72 CA1 (0.31) MAPTCA1CA2CA9
SCHEMBL4261446 0.72 CA1 (0.31) MAPTCA1CA2CA9
SCHEMBL1825729 0.72 CYP1A2 (0.64) CYP1A2MAPTNR1H2NR1H3TRPV1
SCHEMBL1825727 0.72 CYP1A2 (0.64) CYP1A2MAPTNR1H2NR1H3TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003024909-A1 METHOD OF PREPARING SYMMETRICAL POLYHYDROXYSTILBENES L'OREAL (FR) 2003-03-27 WO disclosed