SCHEMBL7190871

SCHEMBL7190871

C=C(C)C(=O)OC[Si](C)(C)OC(=O)C(=C)C

nearest known ligand 0.47

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.47
ALDH1A1 P00352 2/20 0.46
THRB P10828 1/20 0.44
POLB P06746 1/20 0.33
APEX1 P27695 1/20 0.33
HTT P42858 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5401378 0.92 TSHR (0.44) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL332509 0.87 TSHR (0.47) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL2112436 0.85 TSHR (0.39) TSHRALDH1A1THRB
SCHEMBL229519 0.85 TSHR (0.45) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL9915559 0.83 TSHR (0.44) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL1046024 0.83 TSHR (0.44) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL38664045 0.83 ALDH1A1 (0.46) TSHRALDH1A1THRB
SCHEMBL269321 0.82 TSHR (0.50) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL4583359 0.82 TSHR (0.50) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL81163 0.82 THRB (0.48) TSHRALDH1A1THRBPOLBAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105693907-B The preparation method of the silica containing Janus particles of grain size and asymmetric degree controllably 上海交通大学 2018-06-29 CN claimed
CN-105693907-A Preparation method of Janus particle containing silicon dioxide with controllable particle size and asymmetrical degree 上海交通大学 2016-06-22 CN claimed
CN-105524235-A Method for preparing snowman-like organic/inorganic hybrid particles by adopting one-step miniemulsion polymerization method UNIV SHANGHAI JIAOTONG 2016-04-27 CN claimed
EP-0791635-B1 Preapplied silicone threadlocker and sealant LOCTITE CORP (US) 2003-05-02 EP claimed
US-5853520-A Preapplied silicone threadlocker and sealant LOCTITE CORPORATION (US) 1998-12-29 US claimed
EP-0791635-A1 Preapplied silicone threadlocker and sealant LOCTITE CORPORATION (US) 1997-08-27 EP claimed
US-5635546-A CURABLE MIXTURE OF A (METH)ACRYLATE GROUP-CONTAINING SILICONE RESIN IN AN AQUEOUS EMULSION AND A MICROENCAPSULATED PEROXY INITIATOR; STORAGE STABILITY; HIGH STRENGTH; HEAT RESISTANCE; NUTS; BOLTS; SCREWS; FASTENERS LOCTITE CORPORATION (US) 1997-06-03 US claimed
CN-105693907-B The preparation method of the silica containing Janus particles of grain size and asymmetric degree controllably 上海交通大学 2018-06-29 CN disclosed
CN-105524235-B The method that mini-emulsion polymerization one-step method prepares snowman organic inorganic hybridization particle 上海交通大学 2018-06-29 CN disclosed
CN-105693907-A Preparation method of Janus particle containing silicon dioxide with controllable particle size and asymmetrical degree 上海交通大学 2016-06-22 CN disclosed
CN-105524235-A Method for preparing snowman-like organic/inorganic hybrid particles by adopting one-step miniemulsion polymerization method UNIV SHANGHAI JIAOTONG 2016-04-27 CN disclosed
CN-104892944-A Preparation method of (methyl)acryloyloxy methyl-terminiated polysiloxanes UNIV SHANDONG 2015-09-09 CN disclosed
EP-0791635-B1 Preapplied silicone threadlocker and sealant LOCTITE CORP (US) 2003-05-02 EP disclosed
EP-0487291-B1 Photocurable silicon composition, and method of making same LOCTITE CORP (US) 1999-09-29 EP disclosed
EP-0791635-A1 Preapplied silicone threadlocker and sealant LOCTITE CORPORATION (US) 1997-08-27 EP disclosed
US-5635546-A CURABLE MIXTURE OF A (METH)ACRYLATE GROUP-CONTAINING SILICONE RESIN IN AN AQUEOUS EMULSION AND A MICROENCAPSULATED PEROXY INITIATOR; STORAGE STABILITY; HIGH STRENGTH; HEAT RESISTANCE; NUTS; BOLTS; SCREWS; FASTENERS LOCTITE CORPORATION (US) 1997-06-03 US disclosed