Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | PYGL | P06737 | 13/20 | 0.56 |
| ▸ | PYGM | P11217 | 2/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7118162 | 0.94 | MAPT (0.58) | MAPTPYGLPYGMSIRT2SIRT1 | |
| SCHEMBL7126561 | 0.84 | MAPT (0.72) | MAPTPYGLPYGMSIRT2SIRT1 | |
| SCHEMBL7116112 | 0.81 | PLA2G7 (0.40) | MAPTPYGLPYGMALDH1A1KDM4E | |
| SCHEMBL7657400 | 0.81 | LMNA (0.51) | MAPTPYGLALDH1A1MEN1KMT2A | |
| SCHEMBL6432142 | 0.76 | MAPT (0.70) | MAPTPYGLPYGMSIRT2SIRT1 | |
| SCHEMBL7129337 | 0.75 | TP53 (0.41) | MAPTPYGLPYGMALDH1A1KMT2A | |
| SCHEMBL7126028 | 0.73 | MAPT (0.83) | MAPTPYGLPYGMSIRT2SIRT1 | |
| SCHEMBL27716705 | 0.73 | MAPT (0.87) | MAPTPYGLPYGMALDH1A1MEN1 | |
| SCHEMBL4323472 | 0.73 | PYGL (1.00) | MAPTPYGLPYGM | |
| SCHEMBL7124027 | 0.72 | MAPT (0.81) | MAPTPYGLPYGMSIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6590118-B1 | Used in treatment of and/or prevention of diabetes, especially non-insulin dependent diabetes (Type 2 diabetes) | NOVO NORDISK A/S (DK) | 2003-07-08 | — | — | US | disclosed |